Translocation (1;6)(p12;p23) in ANLL

Cancer Genet Cytogenet. 1990 Mar;45(1):67-71. doi: 10.1016/0165-4608(90)90068-l.

Abstract

We report here a case of acute nonlymphocytic leukemia evolving from a myelodysplastic syndrome which developed in an elderly man who had received radiation therapy for a prior cancer. Cytogenetic analysis revealed the following karyotype: 47,XY, + 8,t(1;6)(p13;p23). The breakpoints in the translocation are in the regions of the NRAS1 and PIM1 oncogenes on chromosomes 1 and 6, respectively. This translocation has not been previously observed in hematological malignancies.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Chromosome Banding
  • Chromosomes, Human, Pair 1*
  • Chromosomes, Human, Pair 6*
  • Humans
  • Karyotyping
  • Leukemia, Myeloid, Acute / genetics*
  • Leukemia, Radiation-Induced / genetics*
  • Male
  • Neoplasms / radiotherapy
  • Translocation, Genetic*