Abstract
In order to develop targeted strategies for combating drug resistance it is essential to understand it's basic molecular mechanisms. In an exploratory study we have found several possible indicators of etoposide resistance operating in MCF7VP cells, including up-regulation of ABC transporter genes, modulation of miRNA, and alteration in copy numbers of genes.
Publication types
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Research Support, N.I.H., Intramural
MeSH terms
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Antineoplastic Agents, Phytogenic / pharmacology*
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Breast Neoplasms / drug therapy*
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Breast Neoplasms / genetics*
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Breast Neoplasms / metabolism
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Drug Resistance, Neoplasm / genetics
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Etoposide / pharmacology*
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Female
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Gene Dosage
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Gene Expression Profiling
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Gene Expression Regulation, Neoplastic*
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Humans
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MCF-7 Cells
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MicroRNAs / genetics
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Multidrug Resistance-Associated Proteins / genetics
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Multidrug Resistance-Associated Proteins / metabolism
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Neoplasm Proteins / genetics*
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Neoplasm Proteins / metabolism
Substances
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ABCC6 protein, human
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Antineoplastic Agents, Phytogenic
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MicroRNAs
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Multidrug Resistance-Associated Proteins
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Neoplasm Proteins
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Etoposide
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multidrug resistance-associated protein 1