Oxidative geminal functionalization of organoboron compounds

Angew Chem Int Ed Engl. 2012 Oct 29;51(44):11092-6. doi: 10.1002/anie.201206501. Epub 2012 Oct 4.

Abstract

Excellent tolerance: Stable acylboronates equipped with N-methyliminodiacetyl (MIDA) boryl groups ([B]) were prepared by using a sequence of oxidative manipulations at the boron-bound carbon center (green in scheme). Chemoselective transformations of these acylated organoboron building blocks yielded a range of multifunctionalized boron derivatives and supplied access to valuable borylated heterocycles (see scheme).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Boronic Acids / chemical synthesis
  • Boronic Acids / chemistry*
  • Crystallography, X-Ray
  • Models, Molecular
  • Molecular Structure
  • Oxidation-Reduction

Substances

  • Boronic Acids