Evaluation of dopamine transporters and D2 receptors in hemiparkinsonian rat brains in vivo using consecutive PET scans of [18F]FPCIT and [18F]fallypride

Appl Radiat Isot. 2012 Dec;70(12):2689-94. doi: 10.1016/j.apradiso.2012.08.005. Epub 2012 Aug 19.

Abstract

The aim of this study was to investigate dopaminergic function in unilaterally lesioned 6-OHDA rats by dual PET radioligands: [(18)F]FPCIT (a dopamine transporter imaging radioligand) and [(18)F]fallypride (a dopamine D2 receptors imaging radioligand). As a result, the brain uptake of [(18)F]FPCIT was significantly reduced and that of [(18)F]fallypride was increased in the ipsilateral striatum (lesion side) of the 6-OHDA rats. These findings implicated that dopamine transporter is down-regulated and dopamine D2 receptor is up-regulated in this hemiparkinsonian rat model.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzamides*
  • Corpus Striatum / diagnostic imaging
  • Corpus Striatum / metabolism
  • Dopamine Plasma Membrane Transport Proteins / metabolism*
  • Down-Regulation
  • Fluorine Radioisotopes*
  • Male
  • Oxidopamine
  • Parkinsonian Disorders / chemically induced
  • Parkinsonian Disorders / physiopathology*
  • Positron-Emission Tomography / methods
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Dopamine D2 / metabolism*
  • Tomography, Emission-Computed, Single-Photon
  • Tropanes*
  • Up-Regulation

Substances

  • Benzamides
  • Dopamine Plasma Membrane Transport Proteins
  • Fluorine Radioisotopes
  • Receptors, Dopamine D2
  • Tropanes
  • 2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane
  • Oxidopamine
  • fallypride