Abstract
The 1,4,7-triazacyclononane-1,4,7-tris(methylenephosphinic acid) chelators TRAP and NOPO are complexing copper-64 with similar efficiency as 1,4,7-triazacyclononane-triacetic acid (NOTA). The kinetic stability of Cu-64-labelled TRAP-peptides is sufficient for PET imaging at early time points (1-2 h post injection). For labelling of TRAP conjugates, Cu-64 can be recommended as an alternative to Ga-68 to achieve higher resolution of PET images.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Chelating Agents* / chemistry
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Copper Radioisotopes
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Heterocyclic Compounds* / chemistry
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Humans
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Isotope Labeling
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Melanoma, Experimental / diagnosis*
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Mice
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Mice, Nude
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Molecular Structure
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Phosphinic Acids* / chemistry
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Positron-Emission Tomography
Substances
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1,4,7-tris(methylenephosphinic acid)
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Chelating Agents
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Copper Radioisotopes
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Heterocyclic Compounds
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Phosphinic Acids
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1,4,7-triazacyclononane