2'-Fluoro RNA shows increased Watson-Crick H-bonding strength and stacking relative to RNA: evidence from NMR and thermodynamic data
Angew Chem Int Ed Engl
.
2012 Nov 19;51(47):11863-6.
doi: 10.1002/anie.201204946.
Epub 2012 Oct 10.
Authors
Amritraj Patra
1
,
Michael Paolillo
,
Klaus Charisse
,
Muthiah Manoharan
,
Eriks Rozners
,
Martin Egli
Affiliation
1
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146, USA.
PMID:
23055396
PMCID:
PMC3757553
DOI:
10.1002/anie.201204946
No abstract available
Publication types
Research Support, N.I.H., Extramural
MeSH terms
Hydrogen Bonding
Models, Molecular
Nuclear Magnetic Resonance, Biomolecular
Nucleic Acid Conformation
RNA / chemistry*
Thermodynamics
Substances
RNA
Grants and funding
R01 GM055237/GM/NIGMS NIH HHS/United States
R01 GM071461/GM/NIGMS NIH HHS/United States