Twelve months of routine HIV screening in 6 emergency departments in the Paris area: results from the ANRS URDEP study

PLoS One. 2012;7(10):e46437. doi: 10.1371/journal.pone.0046437. Epub 2012 Oct 2.

Abstract

Objective: In October 2009 the French National Authority for Health recommended that HIV testing be proposed at least once to all persons aged 15 to 70 years in all healthcare settings. We examined whether routine HIV screening with a rapid test in emergency departments (EDs) was feasible without dedicated staff, and whether newly diagnosed persons could be linked to care.

Methods: This one-year study started in December 2009 in 6 EDs in the Paris area, using the INSTI™ test. Eligible individuals were persons 18 to 70 years old who did not present for a vital emergency, for blood or sexual HIV exposure, or for HIV screening. Written informed consent was required.

Results: Among 183 957 eligible persons, 11 401 were offered HIV testing (6.2%), of whom 7936 accepted (69.6%) and 7215 (90.9%) were tested (overall screening rate 3.9%); 1857 non eligible persons were also tested. Fifty-five new diagnoses of HIV infection were confirmed by Western blot (0.61% (95% CI 0.46-0.79). There was one false-positive rapid test result. Among the newly diagnosed persons, 48 (87%) were linked to care, of whom 36 were not lost to follow-up at month 6 (75%); median CD4 cell count was 241/mm(3) (IQR: 52-423/mm(3)).

Conclusions: Screening rates were similar to those reported in opt-in studies with no dedicated staff. The rate of new diagnoses was similar to that observed in free anonymous test centres in the Paris area, and well above the prevalence (0.1%) at which testing has been shown to be cost-effective.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • AIDS Serodiagnosis / statistics & numerical data*
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Emergency Service, Hospital*
  • Female
  • France / epidemiology
  • HIV Infections / diagnosis
  • HIV Infections / epidemiology*
  • Humans
  • Male
  • Middle Aged
  • Young Adult

Grants and funding

The URDEP Study was funded by Agence Nationale de Recherches sur le SIDA et les Hépatites Virales (ANRS), France. After approving the protocol, the study sponsor had no involvement in the study design, data collection, analysis or interpretation, or the writing of the report. Dominique Costagliola had full access to all the study data. Enrique Casalino, Françoise Brun-Vézinet and Dominique Costagliola had final responsibility for the decision to submit for publication.