Solid state grinding as a tool to aid enantiomeric resolution by cocrystallisation

Chem Commun (Camb). 2012 Nov 28;48(92):11340-2. doi: 10.1039/c2cc36130b.

Abstract

The formation of diastereomeric cocrystals of malic acid and tartaric acid was investigated by liquid-assisted grinding in the solid state. We demonstrate that racemic malic acid can be converted into two distinct diastereomeric cocrystal phases by grinding with a single enantiomer of tartaric acid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Crystallization
  • Crystallography, X-Ray
  • Malates / chemistry*
  • Molecular Conformation
  • Stereoisomerism
  • Tartrates / chemistry*

Substances

  • Malates
  • Tartrates
  • malic acid
  • tartaric acid