Polymer nanoreactors shown to produce and release antibiotics locally

Karolina Langowska; Cornelia G Palivan; Wolfgang Meier

doi:10.1039/c2cc36345c

Polymer nanoreactors shown to produce and release antibiotics locally

Chem Commun (Camb). 2013 Jan 7;49(2):128-30. doi: 10.1039/c2cc36345c.

Authors

Karolina Langowska¹, Cornelia G Palivan, Wolfgang Meier

Affiliation

¹ Department of Chemistry, University of Basel, Klingelbergstrasse 80, CH-4056 Basel, Switzerland.

PMID: 23073494
DOI: 10.1039/c2cc36345c

Abstract

We designed and prepared nanoreactors based on a poly(2-methyloxazoline)-block-poly(dimethylsiloxane)-block-poly(2-methyloxazoline (PMOXA-b-PDMS-b-PMOXA) amphiphilic triblock copolymer encapsulating the enzyme penicillin acylase for local and controlled production of antibiotics.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / metabolism*
Anti-Bacterial Agents / pharmacology
Bacteria / drug effects
Bioreactors
Cephalexin / metabolism
Cephalexin / pharmacology
Disk Diffusion Antimicrobial Tests
Nanotechnology
Oxazoles / chemistry*
Penicillin Amidase / metabolism
Polymers / chemistry*

Substances

Anti-Bacterial Agents
Oxazoles
Polymers
poly(2-methyl oxazoline)-block polydimethylsiloxane-block-poly(2-methyl oxazoline)
Penicillin Amidase
Cephalexin