Abstract
We report on the treatment with micafungin of a pacemaker-associated endocarditis due to Candida albicans. Antifungal therapy was able to reduce vegetation size from 5 to 1 cm making possible the transvenous removal of the device without a high risk of pulmonary embolism. Noteworthy, a high micafungin concentration was documented into the lead vegetation (10 μg/g of vegetation tissue) and this may have contributed to the striking size reduction of vegetation.
MeSH terms
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Aged
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Antifungal Agents / therapeutic use*
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Candida albicans / drug effects
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Candida albicans / isolation & purification*
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Echinocandins / therapeutic use*
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Echocardiography
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Endocarditis / diagnosis*
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Endocarditis / drug therapy*
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Endocarditis / microbiology
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Endocarditis / pathology
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Female
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Humans
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Lipopeptides / therapeutic use*
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Micafungin
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Microbial Sensitivity Tests
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Pacemaker, Artificial / adverse effects*
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Prostheses and Implants / adverse effects*
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Treatment Outcome
Substances
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Antifungal Agents
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Echinocandins
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Lipopeptides
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Micafungin