Abstract
We report the complete nucleotide sequence of the pKpS90 plasmid, carrying the bla(KPC-2) and bla(SHV-12) genes. This plasmid was isolated from a sequence type 258 (ST258) Klebsiella pneumoniae strain responsible for an outbreak in a French university hospital in 2009. pKpS90 is a 53,286-bp plasmid that belongs to the IncX incompatibility group. pKpS90 consists of a backbone from IncX plasmids, in which the KPC-2-encoding Tn4401 transposon and a bla(SHV-12)-encoding region have been inserted.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use*
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Base Sequence
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DNA Transposable Elements
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Disease Outbreaks*
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France / epidemiology
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Hospitals, University
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Humans
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Klebsiella Infections / drug therapy
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Klebsiella Infections / epidemiology*
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Klebsiella Infections / microbiology
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Klebsiella pneumoniae / drug effects
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Klebsiella pneumoniae / genetics*
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Klebsiella pneumoniae / isolation & purification
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Plasmids*
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Sequence Analysis, DNA
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beta-Lactam Resistance / genetics*
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beta-Lactamases / genetics*
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beta-Lactams / pharmacology
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beta-Lactams / therapeutic use*
Substances
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Anti-Bacterial Agents
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DNA Transposable Elements
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beta-Lactams
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beta-lactamase SHV-12
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beta-Lactamases
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beta-lactamase KPC-2, Klebsiella pneumoniae