Rhodium-catalyzed regio- and enantioselective amination of racemic secondary allylic trichloroacetimidates with N-methyl anilines

Chem Commun (Camb). 2012 Dec 7;48(94):11531-3. doi: 10.1039/c2cc36961c.

Abstract

We report the chiral diene ligated rhodium-catalyzed dynamic kinetic asymmetric transformation (DYKAT) of racemic secondary allylic trichloroacetimidates with a variety of N-methyl anilines, providing allylic N-methyl arylamines in high yields, regioselectivity, and enantiomeric excess. The rhodium-catalyzed DYKAT method addresses limitations previously associated with this particular class of aromatic nitrogen nucleophiles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetamides / chemistry*
  • Amination
  • Aniline Compounds / chemistry*
  • Catalysis
  • Chloroacetates / chemistry*
  • Rhodium / chemistry*
  • Stereoisomerism
  • Substrate Specificity

Substances

  • Acetamides
  • Aniline Compounds
  • Chloroacetates
  • Rhodium
  • trichloroacetamide
  • aniline