1 Departments of Internal Medicine Gastroenterology and Hepatology Pathology Experimental Immunology Vascular Medicine Experimental Vascular Medicine Clinical Research Unit, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands Department of Paediatrics, University of Oxford, Oxford, UK HIV Pathogenesis Program, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.