Abstract
Two new 14-membered cyclopeptide alkaloids, Oxyphylline B (4) and Oxyphylline C (5), along with three known 13-membered cyclopeptide alkaloids, were isolated from stem and roots of Zizyphus oxyphylla Edgew. The compounds were tested for antibacterial activity. Oxyphylline B (4) showed comparatively better antibacterial activities against Escherichia coli (MIC, 5 μg/mL) than other compounds. This compound also exhibited weak antimicrobial activities against Staphylococcus aureus (MIC, 25 μg/mL), Pseudomonas aeruginosa (MIC, 50 μg/mL) and Salmonella typhi (MIC, 50 μg/mL).
Keywords:
Zizyphus oxyphylla Edgew; antibacterial activity; cyclopeptide alkaloids.
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification
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Alkaloids / pharmacology*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Escherichia coli / drug effects
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Microbial Sensitivity Tests
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Peptides, Cyclic / chemistry
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Peptides, Cyclic / isolation & purification
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Peptides, Cyclic / pharmacology*
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Plant Roots / metabolism
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Plant Stems / metabolism
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Pseudomonas aeruginosa / drug effects
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Salmonella typhi / drug effects
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Staphylococcus aureus / drug effects
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Theophylline / analogs & derivatives*
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Theophylline / chemistry
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Theophylline / isolation & purification
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Theophylline / pharmacology
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Ziziphus / metabolism*
Substances
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Alkaloids
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Anti-Bacterial Agents
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Peptides, Cyclic
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Theophylline
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etofylline