Abstract
Corticosteroid treatment for meningococcal disease is debated. We report a high risk of death (odds ratio 4.68, 95% confidence interval: 1.91-11.46; P = 0.001) without corticosteroid treatment when meningococcal disease is provoked by isolates belonging to the hyperinvasive genotype ST-11. Genotypes of meningococcal isolates should be considered with corticosteroids therapy for meningococcal disease.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adrenal Cortex Hormones / therapeutic use*
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Anti-Inflammatory Agents / therapeutic use*
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Child
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Child, Preschool
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Female
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Genotype
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Humans
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Infant
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Infant, Newborn
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Male
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Meningococcal Infections / drug therapy*
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Meningococcal Infections / microbiology
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Meningococcal Infections / mortality*
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Neisseria meningitidis / classification
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Neisseria meningitidis / genetics
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Neisseria meningitidis / isolation & purification
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Survival Analysis
Substances
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Adrenal Cortex Hormones
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Anti-Inflammatory Agents