Abstract
A series of high-resolution crystal structures of RIG-I and RIG-I:dsRNA cocrystals has recently been reported. Comparison of these structures provides considerable insight into how this innate immune pattern recognition receptor is activated upon detecting and binding a certain class of viral RNAs.
MeSH terms
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Crystallography, X-Ray
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DEAD Box Protein 58
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DEAD-box RNA Helicases / chemistry*
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DEAD-box RNA Helicases / immunology
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DEAD-box RNA Helicases / metabolism*
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Enzyme Activation
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Humans
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Immunity, Innate
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Ligands
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Macromolecular Substances
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Models, Biological
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Models, Molecular
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Protein Conformation
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Protein Multimerization
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RNA, Double-Stranded / chemistry
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RNA, Double-Stranded / metabolism
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RNA, Viral / chemistry
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RNA, Viral / metabolism
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Receptors, Immunologic
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Signal Transduction
Substances
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Ligands
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Macromolecular Substances
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RNA, Double-Stranded
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RNA, Viral
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Receptors, Immunologic
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RIGI protein, human
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DEAD Box Protein 58
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DEAD-box RNA Helicases