Abstract
Subtypes of human immunodeficiency virus type 1 circulating in 21 north Indian patients were characterized based on the partial sequence of the gp120 envelope protein. A majority of viruses (85.7%, 18/21) were subtype C, while 14.3% (3/21) were subtype A. Sequence analysis revealed that the V3 region was highly conserved compared with V4 and V5. The predicted use of co-receptors indicated exclusive usage of R5, except for two subtype A viruses (AIIMS279 and AIIMS281). Our results demonstrate conservation within the V3 loop of subtype C viruses, and suggest the emergence of non-clade C viruses in the north Indian population.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Amino Acid Motifs
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Amino Acid Sequence
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Female
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Genetic Variation*
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HIV Envelope Protein gp120 / chemistry*
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HIV Envelope Protein gp120 / genetics*
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HIV Envelope Protein gp120 / metabolism
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HIV Infections / genetics
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HIV Infections / metabolism*
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HIV Infections / virology
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HIV-1 / classification
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HIV-1 / genetics*
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HIV-1 / isolation & purification*
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HIV-1 / metabolism
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Humans
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India
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Male
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Middle Aged
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Molecular Sequence Data
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Phylogeny
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Receptors, HIV / genetics
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Receptors, HIV / metabolism*
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Sequence Alignment
Substances
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HIV Envelope Protein gp120
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Receptors, HIV
Associated data
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GENBANK/JF300177
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GENBANK/JF320891
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GENBANK/JF320892
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GENBANK/JF320894
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GENBANK/JF320895
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GENBANK/JF320896
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GENBANK/JF320897
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GENBANK/JF320898
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GENBANK/JF320899
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GENBANK/JF320903
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GENBANK/JF320907
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GENBANK/JF320908
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GENBANK/JF320910
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GENBANK/JF320913
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GENBANK/JF320915
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GENBANK/JF320920
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GENBANK/JN019801
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GENBANK/JN019802
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GENBANK/JN019803
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GENBANK/JN019804
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GENBANK/JN019805