No association between TGF-β1 polymorphisms and radiation-induced lung toxicity in a European cohort of lung cancer patients

An M Voets; Cary Oberije; Robin B Struijk; Bart Reymen; Kim De Ruyck; Hubert Thierens; Katrien Vandecasteele; Wilfried De Neve; Ruud Houben; Dirk De Ruysscher; Hubert J M Smeets; Philippe Lambin

doi:10.1016/j.radonc.2012.09.016

No association between TGF-β1 polymorphisms and radiation-induced lung toxicity in a European cohort of lung cancer patients

Radiother Oncol. 2012 Dec;105(3):296-8. doi: 10.1016/j.radonc.2012.09.016. Epub 2012 Nov 3.

Authors

An M Voets¹, Cary Oberije, Robin B Struijk, Bart Reymen, Kim De Ruyck, Hubert Thierens, Katrien Vandecasteele, Wilfried De Neve, Ruud Houben, Dirk De Ruysscher, Hubert J M Smeets, Philippe Lambin

Affiliation

¹ Maastricht University, The Netherlands.

PMID: 23127773
DOI: 10.1016/j.radonc.2012.09.016

Abstract

This study aimed at validating the previously published association between TGF-β1 single nucleotide polymorphisms and a reduced risk for radiation-induced lung toxicity. We were not able to confirm the reported association, neither using maximum dyspnea score nor after correction for baseline dyspnea score.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't
Validation Study

MeSH terms

Adult
Aged
Aged, 80 and over
Carcinoma, Non-Small-Cell Lung / genetics*
Carcinoma, Non-Small-Cell Lung / pathology
Carcinoma, Non-Small-Cell Lung / radiotherapy
Cohort Studies
Dyspnea / etiology
Europe
Female
Follow-Up Studies
Genetic Predisposition to Disease
Genotype
Humans
Lung Neoplasms / genetics*
Lung Neoplasms / pathology
Lung Neoplasms / radiotherapy*
Male
Middle Aged
Neoplasm Staging
Polymorphism, Single Nucleotide*
Radiation Pneumonitis* / genetics
Radiotherapy Dosage
Risk Factors
Small Cell Lung Carcinoma / genetics*
Small Cell Lung Carcinoma / pathology
Small Cell Lung Carcinoma / radiotherapy
Transforming Growth Factor beta1 / genetics*

Substances

Transforming Growth Factor beta1