Abstract
A novel bis(ferrocenyl chalcone) silicon(IV) phthalocyanine has been prepared in which the disulfide linker can be cleaved by dithiothreitol. The separation of the ferrocenyl quencher and the phthalocyanine core greatly enhances the fluorescence emission, singlet oxygen production and in vitro photocytotoxicity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Survival / drug effects
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Chalcone / chemistry*
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Disulfides / chemistry*
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Ferrous Compounds / chemistry
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Humans
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Indoles / chemistry*
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Isoindoles
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MCF-7 Cells
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Metallocenes
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Microscopy, Confocal
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Photosensitizing Agents / chemistry*
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Photosensitizing Agents / toxicity
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Silicon / chemistry
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Singlet Oxygen / chemistry
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Singlet Oxygen / metabolism
Substances
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Disulfides
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Ferrous Compounds
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Indoles
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Isoindoles
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Metallocenes
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Photosensitizing Agents
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Singlet Oxygen
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Chalcone
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ferrocene
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phthalocyanine
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Silicon