Decumbenone C, a new cytotoxic decaline derivative from the marine fungus Aspergillus sulphureus KMM 4640

Olesya I Zhuravleva; Shamil Sh Afiyatullov; Olesya S Vishchuk; Vladimir A Denisenko; Natalya N Slinkina; Olga F Smetanina

doi:10.1007/s12272-012-1007-9

Decumbenone C, a new cytotoxic decaline derivative from the marine fungus Aspergillus sulphureus KMM 4640

Arch Pharm Res. 2012 Oct;35(10):1757-62. doi: 10.1007/s12272-012-1007-9. Epub 2012 Nov 9.

Authors

Olesya I Zhuravleva¹, Shamil Sh Afiyatullov, Olesya S Vishchuk, Vladimir A Denisenko, Natalya N Slinkina, Olga F Smetanina

Affiliation

¹ Far Eastern Federal University, Vladivostok, Russian Federation.

PMID: 23139126
DOI: 10.1007/s12272-012-1007-9

Abstract

A new decaline derivative, decumbenone C (1) along with four known compounds, decumbenones A (2) and B (3), diorcinol (4), and brevianamide F (5) were isolated from the marine fungus Aspergillus sulphureus KMM 4640. Decumbenone C shows potent cytotoxic activity against SK-MEL-5 human melanoma cells with IC(50) values of 0.9 μM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Aspergillus / chemistry*
Aspergillus / isolation & purification
Cell Culture Techniques
Cell Line, Tumor
Cell Proliferation / drug effects
Cell Survival / drug effects
Geologic Sediments* / microbiology
Humans
Inhibitory Concentration 50
Ketones / isolation & purification
Ketones / pharmacology
Molecular Structure
Naphthalenes / isolation & purification*
Naphthalenes / pharmacology
Sesquiterpenes / isolation & purification*
Sesquiterpenes / pharmacology

Substances

Antineoplastic Agents
Ketones
Naphthalenes
Sesquiterpenes
decumbenone A
decumbenone B
decumbenone C