Synthesis of fluorescent ristocetin aglycon derivatives with remarkable antibacterial and antiviral activities

Attila Sipos; Gábor Máté; Erzsébet Rőth; Anikó Borbás; Gyula Batta; Ilona Bereczki; Sándor Kéki; István Jóna; Eszter Ostorházi; Ferenc Rozgonyi; Evelien Vanderlinden; Lieve Naesens; Pál Herczegh

doi:10.1016/j.ejmech.2012.10.030

Synthesis of fluorescent ristocetin aglycon derivatives with remarkable antibacterial and antiviral activities

Eur J Med Chem. 2012 Dec:58:361-7. doi: 10.1016/j.ejmech.2012.10.030. Epub 2012 Oct 25.

Authors

Attila Sipos¹, Gábor Máté, Erzsébet Rőth, Anikó Borbás, Gyula Batta, Ilona Bereczki, Sándor Kéki, István Jóna, Eszter Ostorházi, Ferenc Rozgonyi, Evelien Vanderlinden, Lieve Naesens, Pál Herczegh

Affiliation

¹ Department of Pharmaceutical Chemistry, Medical and Health Science Centre, University of Debrecen, Egyetem tér 1, H-4010 Debrecen, Hungary. [email protected]

PMID: 23149298
DOI: 10.1016/j.ejmech.2012.10.030

Abstract

Isoindole and benzoisoindole derivatives of ristocetin aglycon have been prepared by reaction with o-phthalaldehyde or naphthalene-2,3-dialdehyde and various thiols. The new compounds exhibited potent antibacterial and anti-influenza virus activity. The cluster forming and fluorescent properties of the aglycon derivatives were also studied.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Antiviral Agents / chemical synthesis
Antiviral Agents / chemistry
Antiviral Agents / pharmacology*
Dose-Response Relationship, Drug
Doxorubicin / analogs & derivatives*
Doxorubicin / chemical synthesis
Doxorubicin / chemistry
Doxorubicin / pharmacology
Fluorescence*
Gram-Positive Bacteria / drug effects*
Microbial Sensitivity Tests
Molecular Conformation
Orthomyxoviridae / drug effects*
Structure-Activity Relationship

Substances

Anti-Bacterial Agents
Antiviral Agents
ristocetin aglycon
Doxorubicin