Identity crisis: it's not just Foxp3 anymore

Greg M Delgoffe; Matthew L Bettini; Dario A A Vignali

doi:10.1016/j.immuni.2012.10.012

Identity crisis: it's not just Foxp3 anymore

Immunity. 2012 Nov 16;37(5):759-61. doi: 10.1016/j.immuni.2012.10.012.

Authors

Greg M Delgoffe¹, Matthew L Bettini, Dario A A Vignali

Affiliation

¹ Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Abstract

What does it take to make a regulatory T (Treg) cell? In this issue of Immunity, Ohkura et al. show that Treg-cell-specific CpG hypomethylation and Foxp3 expression are independent events required for Treg cell development, stability, and full suppressive activity.

Publication types

Comment

Grants and funding

F32 AI098383/AI/NIAID NIH HHS/United States