Developing normalized strength scores for neuromuscular research

Muscle Nerve. 2013 Feb;47(2):177-82. doi: 10.1002/mus.23516. Epub 2012 Nov 21.

Abstract

Introduction: The Accurate Test of Limb Isometric Strength (ATLIS) device can reliably measure the strength of 12 muscle groups using a fixed load cell. The purpose of this study was to analyze ATLIS data from healthy adults to calculate an individual's predicted strength scores.

Methods: ATLIS data were collected from 432 healthy adults. Linear regression models were developed to predict each muscle group's strength. The R-squared statistic assessed variability accounted for by the models.

Results: Simple main effects models stratified by gender were used to establish regression equations for each muscle using factors of age, weight, and height.

Conclusions: Normalizing raw strength scores controls for biometric factors, thus enabling meaningful comparisons between subjects and allowing each muscle to contribute equally to a summary score. Normalized scores are easily interpreted for broad clinical uses, and derived summary scores establish individuals' disease progression rates using a common scale, allowing for more efficient clinical trials.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Anthropometry
  • Body Height / physiology
  • Body Weight / physiology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Muscle Strength / physiology*
  • Muscle, Skeletal / physiology*
  • Reference Values