An efficient single-enzymatic cascade for asymmetric synthesis of chiral amines catalyzed by ω-transaminase

Bo Wang; Henrik Land; Per Berglund

doi:10.1039/c2cc37232k

An efficient single-enzymatic cascade for asymmetric synthesis of chiral amines catalyzed by ω-transaminase

Chem Commun (Camb). 2013 Jan 7;49(2):161-3. doi: 10.1039/c2cc37232k. Epub 2012 Nov 20.

Authors

Bo Wang¹, Henrik Land, Per Berglund

Affiliation

¹ KTH Royal Institute of Technology, Division of Biochemistry, School of Biotechnology, AlbaNova University Center, SE-106 91 Stockholm, Sweden.

PMID: 23169388
DOI: 10.1039/c2cc37232k

Abstract

An efficient single-enzymatic cascade approach for the asymmetric synthesis of chiral amines has been developed, which applies the amino donor 3-aminocyclohexa-1,5-dienecarboxylic acid spontaneously tautomerizing to reach reaction completion with excellent ee values.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amination
Amines / metabolism*
Biocatalysis
Chromobacterium / enzymology
Cyclohexanecarboxylic Acids / chemistry
Cyclohexenes / chemistry
Stereoisomerism
Transaminases / metabolism*

Substances

Amines
Cyclohexanecarboxylic Acids
Cyclohexenes
isogabaculine
Transaminases