Functional and molecular insights into KSRP function in mRNA decay

Biochim Biophys Acta. 2013 Jun-Jul;1829(6-7):689-94. doi: 10.1016/j.bbagrm.2012.11.003. Epub 2012 Nov 22.

Abstract

KSRP is a single strand nucleic acid binding protein that controls gene expression at multiple levels. In this review we focus on the recent molecular, cellular, and structural insights into the mRNA decay promoting function of KSRP. We discuss also some aspects of KSRP-dependent microRNA maturation from precursors that are related to its mRNA destabilizing function. This article is part of a Special Issue entitled: RNA Decay mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Binding Sites
  • Cell Line
  • Gene Expression Regulation
  • Humans
  • MicroRNAs / genetics*
  • RNA Stability / genetics*
  • RNA, Messenger / genetics*
  • RNA-Binding Proteins / genetics*
  • RNA-Binding Proteins / metabolism
  • Trans-Activators / genetics*

Substances

  • KHSRP protein, human
  • MicroRNAs
  • RNA, Messenger
  • RNA-Binding Proteins
  • Trans-Activators