Antineutrophil cytoplasmic autoantibody-associated vasculitis in Chinese patients

Peng-Cheng Xu; Min Chen; Ming-Hui Zhao

doi:10.1007/s10157-012-0702-7

Antineutrophil cytoplasmic autoantibody-associated vasculitis in Chinese patients

Clin Exp Nephrol. 2013 Oct;17(5):705-707. doi: 10.1007/s10157-012-0702-7. Epub 2012 Nov 23.

Authors

Peng-Cheng Xu^{1

2

3

4

5}, Min Chen^{1

2

3

4}, Ming-Hui Zhao^{6

7

8

9

10}

Affiliations

¹ Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China.
² Institute of Nephrology, Peking University, Beijing, China.
³ Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China.
⁴ Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, 100034, China.
⁵ Department of Nephrology, General Hospital of Tianjin Medical University, Tianjin, 300052, China.
⁶ Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China. [email protected].
⁷ Institute of Nephrology, Peking University, Beijing, China. [email protected].
⁸ Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China. [email protected].
⁹ Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, 100034, China. [email protected].
¹⁰ Peking-Tsinghua Center for Life Sciences, Beijing, 100871, China. [email protected].

PMID: 23180038
DOI: 10.1007/s10157-012-0702-7

Abstract

Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a common autoimmune disease in China. AAVs in the majority of Chinese patients are microscopic polyangiitis with antigenicity to myeloperoxidase. Propylthiouracil is the leading cause of drug-induced AAV. The genetic background and immunological characteristics of ANCA, such as the epitope, IgG subclass and avidity, might contribute to various clinical phenotypes of AAV.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / blood
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / chemically induced
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / diagnosis
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / ethnology*
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / genetics
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / immunology
Antibodies, Antineutrophil Cytoplasmic / blood
Antithyroid Agents / adverse effects
Asian People* / genetics
Biomarkers / blood
China / epidemiology
Genetic Predisposition to Disease
Humans
Myeloblastin / immunology
Peroxidase / immunology
Phenotype
Prognosis
Propylthiouracil / adverse effects
Risk Factors

Substances

Antibodies, Antineutrophil Cytoplasmic
Antithyroid Agents
Biomarkers
Propylthiouracil
Peroxidase
Myeloblastin