Global control of cell growth in fission yeast and its coordination with the cell cycle

Curr Opin Cell Biol. 2012 Dec;24(6):833-7. doi: 10.1016/j.ceb.2012.10.015. Epub 2012 Nov 22.

Abstract

Cell growth is a fundamental process for every cell but its pleiotropic complexity makes it difficult to comprehend. Global aspects of cellular growth, like the overall determinants of growth rate are not well understood. Here we examine the cell growth pattern of the fission yeast Schizosaccharomyces pombe during the mitotic and meiotic cell cycles. We also explore recent findings illuminating aspects of cell size homeostasis and cell growth regulation, and propose that there are global controls over growth acting at the level of the cell.

Publication types

  • Review

MeSH terms

  • Cell Cycle* / genetics
  • Cell Cycle* / physiology
  • Cell Proliferation
  • Schizosaccharomyces / cytology*
  • Schizosaccharomyces / genetics
  • Schizosaccharomyces / metabolism*
  • Schizosaccharomyces pombe Proteins / genetics
  • Schizosaccharomyces pombe Proteins / metabolism

Substances

  • Schizosaccharomyces pombe Proteins