Reducing bacterial colonization of 3-d nanofiber cell scaffolds by hierarchical assembly of microgels and an antimicrobial Peptide

Qichen Wang; Xiaojun Yu; Matthew Libera

doi:10.1002/adhm.201200306

Reducing bacterial colonization of 3-d nanofiber cell scaffolds by hierarchical assembly of microgels and an antimicrobial Peptide

Adv Healthc Mater. 2013 May;2(5):687-91. doi: 10.1002/adhm.201200306. Epub 2012 Nov 21.

Authors

Qichen Wang¹, Xiaojun Yu, Matthew Libera

Affiliation

¹ Department of Chemical Engineering and Materials Science, Stevens Institute of Technology, Hoboken, New Jersey 07030, USA.

PMID: 23184519
DOI: 10.1002/adhm.201200306

Abstract

The hierarchical electrostatic deposition of anionic microgels and a cationic oligopeptide throughout a PCL-chitosan nanofiber scaffold inhibits S. epidermidis colonization of the scaffold interior while promoting osteoblast adhesion, spreading, and proliferation on the scaffold surface.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Antimicrobial Cationic Peptides / chemistry
Antimicrobial Cationic Peptides / pharmacology*
Cell Survival / drug effects
Drug Carriers / chemistry*
Drug Carriers / pharmacology*
Equipment Contamination / prevention & control*
Equipment Design
Equipment Failure Analysis
Staphylococcus epidermidis / drug effects*
Staphylococcus epidermidis / physiology*
Tissue Scaffolds / microbiology*

Substances

Antimicrobial Cationic Peptides
Drug Carriers