Abstract
A new bifunctional compound NCC, which undergoes thiol-mediated disulfide cleavage after cell entry, produces a red-shifted fluorescent emission in the cytosol and releases free active DNA alkylating agent CLB into the nucleus, and finally leads to DNA damage and cell death.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Alkylating / chemistry*
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Antineoplastic Agents, Alkylating / pharmacology
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Chlorambucil / chemistry
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Chlorambucil / pharmacology
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DNA / genetics
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DNA / metabolism
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DNA Damage
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Disulfides / chemistry
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Drug Carriers / chemistry*
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Drug Design
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HeLa Cells
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Humans
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Intracellular Space / drug effects
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Intracellular Space / metabolism
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Molecular Imaging
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Optical Phenomena
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Spectrometry, Fluorescence
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Sulfhydryl Compounds / chemistry*
Substances
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Antineoplastic Agents, Alkylating
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Disulfides
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Drug Carriers
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Sulfhydryl Compounds
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Chlorambucil
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DNA