Synthesis and pharmacological studies of N-[4-[2-hydroxy-3-[[2-[4-(1H-imidazol-1- yl)phenoxy]ethyl]amino]propoxy]phenyl]methanesulfonamide, a novel antiarrhythmic agent with class II and class III activities

J Med Chem. 1990 Apr;33(4):1087-90. doi: 10.1021/jm00166a002.
No abstract available

MeSH terms

  • Animals
  • Anti-Arrhythmia Agents / chemical synthesis*
  • Chemical Phenomena
  • Chemistry
  • Dogs
  • Electrophysiology
  • Hemodynamics / drug effects
  • Imidazoles / chemical synthesis*
  • Imidazoles / pharmacology
  • Propanolamines / chemical synthesis*
  • Propanolamines / pharmacology
  • Purkinje Fibers / drug effects
  • Purkinje Fibers / physiology
  • Structure-Activity Relationship
  • Sulfonamides / chemical synthesis*
  • Sulfonamides / pharmacology

Substances

  • Anti-Arrhythmia Agents
  • Imidazoles
  • Propanolamines
  • Sulfonamides
  • ersentilide