Are vigabatrin induced T2 hyperintensities in cranial MRI associated with acute encephalopathy and extrapyramidal symptoms?

Eur J Paediatr Neurol. 2013 May;17(3):311-5. doi: 10.1016/j.ejpn.2012.10.009. Epub 2012 Nov 27.

Abstract

Reversible T2-hyperintensities in cranial MRI have been recently observed in infants with infantile spasms, who were treated with vigabatrin. In most cases, this phenomenon is solely been reported in neuroimaging practice without clinical relevance. We report two patients with infantile spasms, who not only developed transient T2-hyperintensities, but also presented acute encephalopathy, and extrapyramidal symptoms under vigabatrin therapy.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Anticonvulsants / adverse effects*
  • Basal Ganglia Diseases / etiology*
  • Down Syndrome / diagnosis
  • Dystonia / etiology*
  • Humans
  • Infant
  • Magnetic Resonance Imaging / methods*
  • Skull / pathology
  • Spasms, Infantile / drug therapy*
  • Treatment Outcome
  • Vigabatrin / adverse effects*

Substances

  • Anticonvulsants
  • Vigabatrin