An interagency collaboration to facilitate development of filovirus medical countermeasures

Viruses. 2012 Oct 19;4(10):2312-6. doi: 10.3390/v4102312.

Abstract

The Filovirus Animal Non-Clinical Group (FANG) is a US interdepartmental and interagency group established to support and facilitate the advanced development of filovirus Medical Countermeasures (MCM), both vaccines and therapeutics. It is co-led by one representative from the Department of Defense (DoD), the first author, and one from the Department of Health and Human Services (HHS), the second author. The FANG membership includes operational level program staff and Subject Matter Experts (SME) from performing organizations as well as scientific staff and program managers from DoD and HHS funding and regulatory agencies. Focus areas include animal models, assays, reagents, product manufacture and characterization, and other interagency product development issues that will support Food and Drug Administration (FDA) licensure of safe and effective filovirus MCMs. The FANG continues to develop strategies to address broadly applicable and interagency product development challenges relevant to filovirus MCM development. This paper summarizes FANG structure and accomplishments and is meant to heighten community awareness of this government-led collaborative effort.

Publication types

  • Editorial

MeSH terms

  • Antiviral Agents / administration & dosage
  • Antiviral Agents / immunology
  • Biomedical Research / organization & administration
  • Cooperative Behavior*
  • Drug Discovery / methods
  • Filoviridae / immunology*
  • Filoviridae / pathogenicity
  • Filoviridae Infections / immunology
  • Filoviridae Infections / prevention & control*
  • Indicators and Reagents / standards
  • Interinstitutional Relations*
  • United States
  • United States Department of Defense / organization & administration
  • United States Dept. of Health and Human Services / organization & administration
  • Virology / methods*
  • Virology / standards

Substances

  • Antiviral Agents
  • Indicators and Reagents