Abstract
Hypothyroid rats show alterations in the mobility of sperm recovered from their epididymides. The AgNOR technique, immunohistochemistry and transmission electron microscopy were used to investigate changes in epithelial cells from epididymides of rats treated with (131)I. Counting of NORs did not permit detection of changes in the proliferative capacity of epididymides of hypothyroid animals. Transmission electron microscopy revealed changes in the mitochondria of hypothyroid rats that probably are associated with incipient apoptosis.
MeSH terms
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Actins / metabolism
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Animals
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Antigens, Nuclear / metabolism
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Apoptosis
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Disease Models, Animal
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Epididymis / metabolism
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Epididymis / ultrastructure*
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Epithelial Cells / metabolism
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Epithelial Cells / ultrastructure
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Hypothyroidism / metabolism
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Hypothyroidism / pathology*
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Immunohistochemistry
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Male
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Microscopy, Electron, Transmission
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Mitochondria / metabolism
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Mitochondria / ultrastructure*
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Rats
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Rats, Wistar
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Receptors, Thyroid Hormone / metabolism
Substances
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Actins
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Antigens, Nuclear
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Receptors, Thyroid Hormone
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nucleolar organizer region associated proteins