The role of T-cells in the pathogenesis of myelodysplastic syndromes: passengers and drivers

Claudio Fozza; Maurizio Longinotti

doi:10.1016/j.leukres.2012.11.007

The role of T-cells in the pathogenesis of myelodysplastic syndromes: passengers and drivers

Leuk Res. 2013 Feb;37(2):201-3. doi: 10.1016/j.leukres.2012.11.007. Epub 2012 Dec 3.

Authors

Claudio Fozza¹, Maurizio Longinotti

Affiliation

¹ Department of Biomedical Sciences, University of Sassari, Sassari, Italy. [email protected]

PMID: 23218025
DOI: 10.1016/j.leukres.2012.11.007

Abstract

Although a burden of clinical and experimental data suggest the involvement of T-lymphocytes in the pathogenesis of myelodysplastic syndromes (MDS), the actual weight exerted by T-cells in this scenario is yet to be conclusively dissected. This brief review will try to further address this point, by running through the most relevant studies exploring the T-cell repertoire of MDS patients as well as the potential role of specific T-cell subsets such as regulatory T-cells and Th17 T-cells.

Publication types

Review

MeSH terms

Humans
Myelodysplastic Syndromes / immunology*
Myelodysplastic Syndromes / metabolism*
Myelodysplastic Syndromes / therapy
T-Lymphocyte Subsets / immunology
T-Lymphocyte Subsets / metabolism
T-Lymphocytes / immunology*
T-Lymphocytes / metabolism*