[Reynolds syndrome revealing a malignant thymoma]

M Michaud; C Gaudin; D Brechemier; G Moulis; L Astudillo; V Lavialle-Guillotreau; L Balardy

doi:10.1016/j.revmed.2012.10.374

[Reynolds syndrome revealing a malignant thymoma]

Rev Med Interne. 2013 Mar;34(3):171-3. doi: 10.1016/j.revmed.2012.10.374. Epub 2012 Dec 4.

[Article in French]

Authors

M Michaud¹, C Gaudin, D Brechemier, G Moulis, L Astudillo, V Lavialle-Guillotreau, L Balardy

Affiliation

¹ Service de médecine interne, hôpital de Purpan, CHU de Toulouse, Toulouse, France. [email protected]

PMID: 23218067
DOI: 10.1016/j.revmed.2012.10.374

Abstract

Introduction: Thymomas, benign or malignant, may be associated with autoimmune diseases. They are classically associated with myasthenia gravis, neuromyotonia, or pure red cell aplasia.

Case report: We here report, to the best of our knowledge, the first description of an association between thymoma and Reynolds syndrome (systemic sclerosis associated with primary biliary cirrhosis) in an 80-year-old woman.

Conclusion: The suspected pathogenesis of this association could be a thymus escape of auto-reactive T lymphocytes and the consecutive development of an auto-immune disorder.

Publication types

Case Reports
English Abstract

MeSH terms

Aged, 80 and over
Female
Humans
Liver Cirrhosis, Biliary / diagnosis*
Scleroderma, Systemic / diagnosis*
Sjogren's Syndrome / diagnosis
Syndrome
Thymoma / diagnosis*
Thymus Neoplasms / diagnosis*