Nutritional risk and gastrointestinal dysautonomia symptoms in Parkinson's disease outpatients hospitalised on a scheduled basis

Br J Nutr. 2013 Jul 28;110(2):347-53. doi: 10.1017/S0007114512004941. Epub 2012 Dec 11.

Abstract

Dysautonomia symptoms of nutritional interest may often occur in Parkinson's disease (PD), but the role played in affecting the risk of malnutrition still needs to be clarified. A total of 208 consecutive PD outpatients hospitalised on a scheduled basis were assessed for nutritional risk by the Malnutrition Universal Screening Tool. Presence of dysautonomia symptoms (dysphagia, sialorrhoea and constipation) was investigated using clinical rating scales. In our population, prevalence of nutritional risk was 17·2 (95 % CI 12·1, 24·0) % and relied mainly on unintentional weight loss. Sialorrhoea, dysphagia, dysphagia to liquids and constipation were observed in 10·6, 11·0, 14·4 and 59·6 % of the patients, respectively. Nutritional risk was independently associated with the number of dysautonomia symptoms (OR 1·39 (95 % CI 1·00, 1·96); P= 0·048) but not with single symptoms. An independent association was also found with the severity of motor symptoms (Hoehn-Yahr stage, OR 1·48 (95 % CI 1·00, 2·55); P= 0·049) and levodopa dose (OR 1·16 (95 % CI 1·04, 1·31) mg/kg per d; P= 0·009). Nutritional risk in PD outpatients appears to depend mainly on dysautonomic syndrome, disease severity and levodopa dosage. Implications for outcome deserve further investigation. The assessment of nutritional status and of gastrointestinal dysautonomia symptoms should be part of the routine work-up of a PD patient.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Confidence Intervals
  • Constipation / epidemiology
  • Constipation / etiology
  • Deglutition Disorders / epidemiology
  • Deglutition Disorders / etiology
  • Female
  • Gastrointestinal Diseases / epidemiology
  • Gastrointestinal Diseases / etiology*
  • Hospitalization
  • Humans
  • Levodopa / administration & dosage
  • Levodopa / adverse effects*
  • Levodopa / therapeutic use
  • Male
  • Malnutrition* / epidemiology
  • Malnutrition* / etiology
  • Middle Aged
  • Nutritional Status
  • Odds Ratio
  • Outpatients
  • Parkinson Disease / complications*
  • Prevalence
  • Primary Dysautonomias* / epidemiology
  • Primary Dysautonomias* / etiology
  • Risk Factors
  • Severity of Illness Index*
  • Sialorrhea* / epidemiology
  • Sialorrhea* / etiology
  • Weight Loss

Substances

  • Levodopa