Pseudothrombocytopenia in a neonate due to mother?

Eur J Pediatr. 2013 Jul;172(7):987-9. doi: 10.1007/s00431-012-1892-4. Epub 2012 Nov 16.

Abstract

Ethylenediaminetetraacetic acid (EDTA)-dependent pseudothrombocytopenia (PTCP) is the phenomenon of a false low platelet count reported by an automated haematology analyzer due to in vitro aggregation of platelets. This aggregation is due to the interaction between antibodies and EDTA-dependent crypt antigens on platelets. We observed a new born child whose mother was diagnosed with transient PTCP due to transplacental transmission of maternal immunoglobulin G antibodies during pregnancy.

Conclusion: Although maternal-neonatal PTCP is rare, it is important to consider this phenomenon as a cause of trombocytopenia, as it can result in unnecessary diagnostic workup and treatment.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anticoagulants / adverse effects*
  • Blood Platelets / immunology*
  • Edetic Acid / adverse effects*
  • Female
  • Humans
  • Immunoglobulin G / analysis
  • Infant, Newborn
  • Maternal-Fetal Exchange / immunology*
  • Pregnancy
  • Thrombocytopenia / chemically induced*

Substances

  • Anticoagulants
  • Immunoglobulin G
  • Edetic Acid