Abstract
Four new phenolic compounds, caesalpiniaphenols A-D (1-4), together with eight known compounds were isolated from Caesalpinia sappan heartwood. The chemical structures were established mainly by NMR, MS, ECD, and Mosher's method. Compounds 4, 5, and 7 showed weak inhibitory activity against the LPS-induced NO production in macrophage RAW264.7 cells with IC(50) values of 12.2, 3.5, and 5.7 μM, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Caesalpinia / chemistry*
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Inhibitory Concentration 50
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Lipopolysaccharides / pharmacology
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Macrophages / drug effects
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Mice
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Molecular Structure
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Nitric Oxide / analysis
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Nitric Oxide / biosynthesis
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Nuclear Magnetic Resonance, Biomolecular
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Phenols / chemistry
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Phenols / isolation & purification*
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Phenols / pharmacology*
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Republic of Korea
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Wood / chemistry
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Lipopolysaccharides
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Phenols
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caesalpiniaphenol D
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Nitric Oxide