Tricuspid dysfunction appeared in a 47 year-old woman fifteen months after multiple valvular surgery, including aortic and tricuspid valvular replacement with Duromedics valves. At reoperation one of the leaflets of the tricuspid prosthesis was blocked with overgrown tissue from the native tricuspid annulus. The prosthesis was replaced with another Duromedics valve and the patient is doing well nineteen months later. This case, is the first report of dysfunction of a Duromedics mechanical cardiac valve inserted in the tricuspid position.