IL-23 in colitis: targeting the progenitors

Ce Tang; Yoichiro Iwakura

doi:10.1016/j.immuni.2012.11.010

IL-23 in colitis: targeting the progenitors

Immunity. 2012 Dec 14;37(6):957-9. doi: 10.1016/j.immuni.2012.11.010.

Authors

Ce Tang¹, Yoichiro Iwakura

Affiliation

¹ Research Institute for Biomedical Sciences, Tokyo University of Science, Yamazaki 2669, Noda-shi, Chiba, Japan.

PMID: 23244717
DOI: 10.1016/j.immuni.2012.11.010

Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract. In this issue of Immunity, Griseri et al. (2012) show that IL-23-induced dysregulation of hematopoietic stem and progenitor cells contributes to the pathogenesis of two IBD models.

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