Signaling cascades initiated by TSLP-mediated signals in different cell types

Xiaozhou Yu; Hui Li; Xiubao Ren

doi:10.1016/j.cellimm.2012.10.005

Signaling cascades initiated by TSLP-mediated signals in different cell types

Cell Immunol. 2012 Oct;279(2):174-9. doi: 10.1016/j.cellimm.2012.10.005. Epub 2012 Oct 29.

Authors

Xiaozhou Yu¹, Hui Li, Xiubao Ren

Affiliation

¹ Department of Immunology, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, China.

PMID: 23246679
DOI: 10.1016/j.cellimm.2012.10.005

Abstract

Thymic stromal lymphopoietin (TSLP) has been well characterized as a consequence of its ability to modulate allergic and neoplastic diseases. However, downstream signaling mediated by TSLP varies significantly between the cell type and species examined. Since this observation is often overlooked and in some cases ignored, this review aims to consolidate the molecular pathways activated by TSLP receptors expressed by various human and mouse cell types.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
B-Lymphocytes / metabolism
Cells, Cultured
Cytokines / metabolism*
Dendritic Cells / metabolism
Eosinophils / metabolism
Humans
Mice
Signal Transduction*
T-Lymphocytes / metabolism
Thymic Stromal Lymphopoietin
Trophoblasts / metabolism

Substances

Cytokines
Thymic Stromal Lymphopoietin