Direct α-functionalization of simple aldehydes via oxidative N-heterocyclic carbene catalysis

Org Lett. 2013 Jan 4;15(1):50-3. doi: 10.1021/ol303035r. Epub 2012 Dec 18.

Abstract

A direct α-functionalization of simple aldehydes under N-Heterocyclic Carbene (NHC) catalysis and direct generation of ester enolate equivalents from nonfunctionalized aldehydes are disclosed. The catalysis involves selective enolate generation from an oxidatively generated NHC-bounded ester intermediate as a key step. The ester enolate intermediates undergo stereoselective reactions with enones and trifluoromethyl ketones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry*
  • Catalysis
  • Heterocyclic Compounds / chemistry*
  • Ketones / chemistry
  • Methane / analogs & derivatives*
  • Methane / chemistry
  • Molecular Structure
  • Oxidation-Reduction

Substances

  • Aldehydes
  • Heterocyclic Compounds
  • Ketones
  • carbene
  • Methane