Molecular mechanisms driving respiratory syncytial virus assembly

Future Microbiol. 2013 Jan;8(1):123-31. doi: 10.2217/fmb.12.132.

Abstract

Respiratory syncytial virus is a single-stranded RNA virus in the Paramyxoviridae family that preferentially assembles and buds from the apical surface of polarized epithelial cells, forming filamentous structures that contain both viral proteins and the genomic RNA. Recent studies have described both viral and host factors that are involved in ribonucleoprotein assembly and trafficking of viral proteins to the cell surface. At the cell surface, viral proteins assemble into filaments that probably require interactions between viral proteins, host proteins and the cell membrane. Finally, a membrane scission event must occur to release the free virion. This article will review the recent literature describing the mechanisms that drive respiratory syncytial virus assembly and budding.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Membrane / metabolism
  • Cytoskeleton / metabolism
  • Host-Pathogen Interactions
  • Humans
  • Protein Transport
  • Respiratory Syncytial Viruses / physiology*
  • Ribonucleoproteins / metabolism
  • Viral Fusion Proteins / metabolism
  • Viral Proteins / metabolism
  • Virus Assembly*
  • Virus Release

Substances

  • F protein, human respiratory syncytial virus
  • Ribonucleoproteins
  • Viral Fusion Proteins
  • Viral Proteins