Cell-based vasculogenic studies in preclinical models of chronic myocardial ischaemia and hibernation

Expert Opin Biol Ther. 2013 Mar;13(3):411-28. doi: 10.1517/14712598.2013.748739. Epub 2012 Dec 21.

Abstract

Introduction: Coronary artery disease commonly leads to myocardial ischaemia and hibernation. Relevant preclinical models of these conditions are essential to evaluate new therapeutic options such as cell-based vasculogenic therapies.

Areas covered: In this article, the authors first review basic concepts of myocardial ischaemia/hibernation and relevant techniques to assess myocardial viability. Then, preclinical models of chronic myocardial ischaemia and hibernation, induced by devices such as ameroid constrictors, Delrin stenosis, hydraulic occluders, and coils/stents are described. Lastly, the authors discuss cell-based vasculogenic therapy, and summarise studies conducted in large animal models of chronic myocardial ischaemia and hibernation.

Expert opinion: Approximately one-third of patients with viable myocardium do not undergo revascularisation; however, this population is at high risk for cardiac events and would surely benefit from effective cell-based therapy. Because of the modest benefits in clinical studies, preclinical models accurately representing clinical myocardial ischemia/hibernation are necessary to better understand and appropriately direct regenerative therapy research.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chronic Disease
  • Disease Models, Animal*
  • Humans
  • Myocardial Ischemia / pathology*
  • Myocardial Stunning / pathology*
  • Neovascularization, Pathologic / pathology*