C(22)-steroidal lactone glycosides from stems and leaves of Paris polyphylla var. yunnanensis

Xu-Jie Qin; Chang-Xiang Chen; Wei Ni; Huan Yan; Hai-Yang Liu

doi:10.1016/j.fitote.2012.12.007

C(22)-steroidal lactone glycosides from stems and leaves of Paris polyphylla var. yunnanensis

Fitoterapia. 2013 Jan:84:248-51. doi: 10.1016/j.fitote.2012.12.007. Epub 2012 Dec 20.

Authors

Xu-Jie Qin¹, Chang-Xiang Chen, Wei Ni, Huan Yan, Hai-Yang Liu

Affiliation

¹ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650201, PR China.

PMID: 23262268
DOI: 10.1016/j.fitote.2012.12.007

Abstract

Further phytochemical investigation on the stems and leaves of Paris polyphylla var. yunnanensis has led to the isolation of three C(22)-steroidal lactone glycosides. Two of these are new compounds, designated as chonglouoside SL-7 (1) and chonglouoside SL-8 (2). Their structures were elucidated on the basis of extensive spectroscopic analysis, as well as comparison with the reported spectroscopic data. This is the first report of C(22)-steroidal lactone glycosides isolated from the Paris genus. Compounds 1 and 3 showed moderate antimicrobic activity against Propionibacterium acnes with MIC values of 31.3 and 3.9μg/mL, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Glycosides / chemistry*
Magnoliopsida / chemistry*
Molecular Structure
Phytosterols / chemistry*
Plant Components, Aerial
Plant Leaves / chemistry*
Plant Stems / chemistry*

Substances

Glycosides
Phytosterols
chonglouoside SL-7
chonglouoside SL-8