Abstract
The prognostic value of renal biopsy in anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis is widely recognized; however, there is no consensus regarding its pathological classification. Berden et al. proposed a new classification of glomerulonephritis in ANCA-associated vasculitis (AAV) categorized into focal, crescentic, mixed, and sclerotic classes and showed its prognostic value in 100 international multicenter cohorts for 1- and 5-year renal outcomes. In order to evaluate whether this new classification has predictive value and reproducibility in Japanese AAV cases, 87 cohorts with only microscopic polyangiitis in 3 limited centers in Japan were analyzed. In addition, those from Japan, Europe (Berden's cohorts) and China were compared in a recent report.
Publication types
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Comparative Study
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / classification
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Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / epidemiology
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Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / immunology
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Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / pathology*
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Antibodies, Antineutrophil Cytoplasmic / blood*
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Biomarkers / blood
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Biopsy
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China / epidemiology
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Disease Progression
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Europe / epidemiology
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Female
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Glomerulonephritis / classification
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Glomerulonephritis / epidemiology
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Glomerulonephritis / immunology
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Glomerulonephritis / pathology*
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Humans
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Japan / epidemiology
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Kidney Failure, Chronic / epidemiology
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Kidney Failure, Chronic / immunology
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Kidney Failure, Chronic / pathology
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Kidney Glomerulus / immunology
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Kidney Glomerulus / pathology*
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Male
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Middle Aged
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Peroxidase / immunology*
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Predictive Value of Tests
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Prognosis
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Terminology as Topic
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Time Factors
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Young Adult
Substances
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Antibodies, Antineutrophil Cytoplasmic
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Biomarkers
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Peroxidase