Abstract
Several non-benzimidazole containing inhibitors of respiratory syncytial virus are described. Core template modification, analysis of antiviral activity, physicochemistry and optimisation of properties led to the thiazole-imidazole 13, that showed a good potency and pharmacokinetic profile in the rat.
Copyright © 2012 Elsevier Ltd. All rights reserved.
MeSH terms
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Animals
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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Benzimidazoles / chemistry
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Imidazoles / chemical synthesis
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Imidazoles / pharmacokinetics
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Imidazoles / pharmacology
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Inhibitory Concentration 50
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Rats
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Respiratory Syncytial Viruses / drug effects*
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Structure-Activity Relationship
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Thiazoles / chemical synthesis
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Thiazoles / pharmacokinetics
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Thiazoles / pharmacology
Substances
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Antiviral Agents
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Benzimidazoles
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Imidazoles
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Thiazoles
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imidazole
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benzimidazole