This is a case of a 58-year-old woman who underwent mastectomy for advanced right breast cancer (T2N2M0, stage IIIA, ER+, PR+, and HER2 0) at another hospital 13 years ago. Tamoxifen was administered after the operation. Two years later, bone and lung metastases appeared and she was transferred to our hospital. Hormonal therapies, epirubicin- cyclophosphamide-5-FU, doxifluridine, paclitaxel, vinorelbine, and capecitabine were ineffective. We planned a sixth-line chemotherapy comprising gemcitabine combined with docetaxel, but not paclitaxel. Partial response was obtained by treatment with 3 courses of gemcitabine-docetaxel. The same treatment was continued and the patient is alive in a good condition without progression for 14 months.