Minor fluctuations in renal function may alter therapeutic drug concentrations substantially during high-dose, continuous-infusion beta-lactam therapy for multi-drug-resistant Gram-negative bacilli

MeSH terms

• Administration, Intravenous
• Aged
• Anti-Bacterial Agents / administration & dosage*
• Anti-Bacterial Agents / blood*
• Drug Monitoring
• Drug Resistance, Multiple, Bacterial
• Glomerular Filtration Rate
• Gram-Negative Bacteria / drug effects
• Gram-Negative Bacteria / isolation & purification
• Gram-Negative Bacterial Infections / blood
• Gram-Negative Bacterial Infections / drug therapy*
• Gram-Negative Bacterial Infections / metabolism*
• Humans
• Kidney / drug effects
• Kidney / metabolism*
• Kidney Function Tests
• Male
• Meropenem
• Microbial Sensitivity Tests
• Thienamycins / administration & dosage*
• Thienamycins / blood*