Abstract
Chimeric polypeptides (CPs) that are derived from elastin-like polypeptides (ELPs) can self-assemble to form nanoparticles by site-specific covalent attachment of hydrophobic molecules to one end of the biopolymer backbone. Molecules with a distribution coefficient greater than 1.5 impart sufficient amphiphilicity to drive self-assembly into sub-100 nm nanoparticles.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Amino Acid Sequence
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Deoxycytidine / analogs & derivatives
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Deoxycytidine / chemistry
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Drug Carriers / chemistry*
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Gemcitabine
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Hydrophobic and Hydrophilic Interactions
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Nanoparticles / chemistry*
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Oxycodone / chemistry
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Paclitaxel / chemistry
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Peptides / chemistry*
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Pharmaceutical Preparations / chemistry*
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Polymers / chemistry*
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Temperature
Substances
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Drug Carriers
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Peptides
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Pharmaceutical Preparations
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Polymers
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Deoxycytidine
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Oxycodone
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Paclitaxel
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Gemcitabine